Taxane pathway
نویسندگان
چکیده
منابع مشابه
Taxane-Induced Peripheral Neurotoxicity
Taxane-derived agents are chemotherapy drugs widely employed in cancer treatment. Among them, paclitaxel and docetaxel are most commonly administered, but newer formulations are being investigated. Taxane antineoplastic activity is mainly based on the ability of the drugs to promote microtubule assembly, leading to mitotic arrest and apoptosis in cancer cells. Peripheral neurotoxicity is the ma...
متن کاملScalable, enantioselective taxane total synthesis
Taxanes form a large family of terpenes comprising over 350 members, the most famous of which is Taxol (paclitaxel), a billion-dollar anticancer drug. Here, we describe the first practical and scalable synthetic entry to these natural products via a concise preparation of (+)-taxa-4(5),11(12)-dien-2-one, which has a suitable functional handle with which to access more oxidized members of its fa...
متن کاملFarnesyltransferase inhibitors reverse taxane resistance.
The combination of farnesyltransferase inhibitors (FTIs) and taxanes has been shown to result in potent antiproliferative and antimitotic synergy. Recent phase I and II clinical trials have shown that this combination shows clinical activity in taxane-refractory or taxane-resistant cancer patients. To understand the mechanism behind these clinical observations, we used a cancer cell model of pa...
متن کاملTaxane resistance in breast cancer
Despite recent progress in the treatment of breast cancer, disease recurrence remains a major issue to curative therapy. One of the major clinical issues is the development of drug resistance. Taxane resistance is a big challenge because taxanes, either alone or in combination, is the first-line regimens for treating breast cancer. A hierarchy of resistant mechanisms are responsible for taxane ...
متن کاملCancer Therapy: Preclinical Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors
Purpose: Taxanes are important chemotherapeutic agents with proven efficacy in human cancers, but their use is limited by resistance development. We report here the preclinical characteristics of cabazitaxel (XRP6258), a semisynthetic taxane developed to overcome taxane resistance. Experimental Design:Cabazitaxel effects on purified tubulin and on taxane-sensitive or chemotherapyresistant tumor...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2009
ISSN: 1744-6872
DOI: 10.1097/fpc.0b013e3283335277